Copa Sul-Americana 2021First Phase - 1st Leg | ||
| 1 - 2 | 
|
| Guaireña [PAR] | River Plate [PAR] | |
| Guaireña Fútbol Club | Club Atlético River Plate | |
| Venue | Defensores del Chaco, Asunción, Paraguay (Estádio Defensores del Chaco) |
| Date | 03/18/2021 - Thursday |
| Time | 18:15 [UTC-4] |
| Goals |
| Guaireña [PAR] |
| Gonzales 51 |
| River Plate [PAR] |
| Zeballos 62, Otazu 90+1 |
| Lineups | ||||
| Guaireña [PAR]
| ||||
 | Gonzales | 51 | ||
| River Plate [PAR]
| ||||
| | Zeballos | 62 | ||
| | Otazu | 90+1 | ||
