Copa Sul-Americana 2022Third Phase - Round of 16 - 2nd Leg | ||
| 1 - 2 | 
|
| Unión Santa Fe [ARG] | Nacional [URU] | |
| Club Atlético Unión | Club Nacional de Football | |
| Venue | 15 de Abril, Santa Fe, Argentina (Estadio 15 de Abril) |
| Date | 07/05/2022 - Tuesday |
| Time | 19:15 [UTC-3] |
 Video | |
| Goals |
 Unión Santa Fe [ARG] |
| Britez 70 |
 Nacional [URU] |
| Ramirez 77, Rodriguez 83 |
| Lineups | ||||
| Unión Santa Fe [ARG]
| ||||
 | Britez | 70 | ||
| Nacional [URU]
| ||||
| | Ramirez | 77 | ||
| | Rodriguez | 83 | ||
| Observations |
| Nacional [URU] qualified |
