Copa Sul-Americana 2022Second Phase - Round 6 | ||
| 0 - 2 | 
|
| Defensa y Justicia [ARG] | Antofagasta [CHI] | |
| Club Social y Deportivo Defensa y Justicia | Club de Deportes Antofagasta S.A.D.P. | |
| Venue | Norberto Tito Tomaghello, Buenos Aires, Argentina (Estádio Norberto Tito Tomaghello) |
| Date | 05/24/2022 - Tuesday |
| Time | 21:30 [UTC-3] |
 Video | |
| Goals |
 Antofagasta [CHI] |
| Hurtado 42, Manuel Lopez 73 |
| Lineups | ||||
| Antofagasta [CHI]
| ||||
 | Hurtado | 42 | ||
| | Manuel Lopez | 73 | ||
